What are the physical and psychological effects of drug abuse and addiction?

What are the physical and psychological effects of drug abuse and addiction?
While the specific physical and psychological effects of drug abuse and addiction tend to vary depending on the particular substance involved, the overall effects of abuse or addiction to a drug can be devastating. Psychologically, intoxication or withdrawal of a substance can cause any of the euphoria that alcohol, ecstasy or intoxication by inhalation, paranoia marijuana...
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